That's technically false. Fundamental defensive line play dictates that the QB be considered a runner by the backside defensive end. He is supposed to aim for the backfield half of the QB on any runs that go away from him until it is determined that he doesn't have the ball. This is supposed to prevent bootleg runs and reverses.
The spread option forces the defense to stay true to their fundamentals and not bite on the possible handoff. The more this style gets run int pros the more consistently the defensive linemen will stick to their responsibilities and not go for the glory.
It may be technically false, but it's more of a practical concern when you are facing RG3 than Peyton Manning, who I don't think we're going to see running zone read anytime soon. I think your 2nd paragraph supports what I was aiming at about Ds cheating (again, as a practical option when you're not facing a mobile QB).
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