The WVU oline vs Mizzou dline is the stuff that draft experts will probably look at but Mizzou's D isn't actually all that good on 3rd down or red zone. Their specialty is getting negative plays and without that the D is pretty average. That said, WVU gave up a lot of TFLs last year so I can see Mizzou holding them to around 20 points.
Can Mizzou's offense actually score? Last year the oline was timid and lost, the running game lacked big play power and the offense was running an inept Freshman QB and even more inept WRs. It was the softest offense you'll ever see. This year the oline is brand new (and unproven), the RBs will be new (and more proven), the QB is the same, the WRs are the same. Heupel is the new OC and he is known for being a good QB guy and a bad play caller. I think the offensive output will probably be around 17 points but I think thats a highly variable number.
So 20-17 WVU over Mizzou would be my prediction before factoring in things like turnovers. I like if WVU plays sloppy then Mizzou can win.