If Jeffery and Marshall are out it is sneaky. I am hearing Marshall will play though. Not sure about Jeffery, but only Marshall is needed to make holmes irrelevant.
Holmes could be a sneaky play. As Han Solo said, "I got a bad feeling about this." The Bears' O-line might be missing Garza and Slauson. (strike 1) And the Niners seem to have the Bears' number. (strike 2) Plus it's a prime time game. (strike 3) Maybe I'm just pessimistic, but Bennett may be the most targeted guy out there besides Forte.
If Holmes faces double coverage, the sneakier play may be Josh Bellamy. But I'm not touching either Holmes or Bellamy.