The smart, safe play is Foles
The risky gamble that could pay off big is Locker. Although to get big points from Locker, you must assume that Romo won't give the game away before halftime again also.
I'd play Foles, the Eagles - Colts winner will probably score in the 30's oh and loser just might too. Tennessee's O-line will probably dominate and they could run alot on Dallas.
If you draft a Rodgers, Brees, or Manning early in the draft (first 3 rounds IMO), I think it is ridiculous to call them a waste. Almost always those guys will give you more fantasy points than you would have gotten from a RB In the same position