This the same league you asked the QB/TE question on? If so, A. Holmes is a better drop than Wayne.
Bryant is tending up, target wise and snap count wise, but he's still low on the volume. He's a bigger risk at being shut out than Wayne is, but his ceiling is immense. That's a gamble, one I wouldn't suggest, but sure wouldn't argue too hard against it either.
I would drop Wayne over Holmes... Call me crazy, but Holmes has a higher ceiling at this point, and is more predictable... and if you stream Bryant and holmes you are getting a great high ceiling flex or WR3 option... Wayne might be more consistent, but his ceiling is just not that high...
Lol. I was just thinking the same thing. Funny thing is, he's on my bench, but I don't even need him. I had this week won before tonight and I had three guys including Luck going.